An Epidemiology of Big Data

Federal legislation designed to transform the U.S. healthcare system and the emergence of mobile technology are among the common drivers that have contributed to a data explosion, with industry analysts and stakeholders proclaiming this decade the big data decade in healthcare (Horowitz, 2012). But a precise definition of big data is hazy (Dumbill, 2013). Instead, the healthcare industry mainly relies on metaphors, buzzwords, and slogans that fail to provide information about big data\u27s content, value, or purposes for existence (Burns, 2011). Bollier and Firestone (2010) even suggests big data does not really exist in healthcare (p. 29). While federal policymakers and other healthcare stakeholders struggle with the adoption of Meaningful Use Standards, International Classification of Diseases-10 (ICD-10), and electronic health record interoperability standards, big data in healthcare remains a widely misunderstood phenomenon. Borgman (2012) found by studying how data are created, handled, and managed in multi-disciplinary collaborations, we can inform science policy and practice (p. 12). Through the narratives of nine leaders representing three key stakeholder classes in the healthcare ecosystem: government, providers and consumers, this phenomenological research study explored a fundamental question: Within and across the narratives of three key healthcare stakeholder classes, what are the important categories of meaning or current themes about big data in healthcare? This research is significant because it: (1) produces new thematic insights about the meaning of big data in healthcare through narrative inquiry; (2) offers an agile framework of big data that can be deployed across all industries; and, (3) makes a unique contribution to scholarly qualitative literature about the phenomena of big data in healthcare for future research on topics including the diffusion and spread of health information across networks, mixed methods studies about big data, standards development, and health policy

Research exercise: ETHOS - Appropriate Solar Technology for Bihar, India

An investigation of the potential for appropriate solar technology in Bihar, India, including solar thermal refrigeration systems. The feasibility of solar PV cells within a micro grid system was studied for applications to existing refrigerators. This is pre-work for an upcoming ETHOS immersion in Bihar, India.https://ecommons.udayton.edu/stander_posters/1572/thumbnail.jp

Annular Engine Development Status

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106479/1/AIAA2013-3892.pd

Downstream Improvement for Recombinant Adeno-Associated Viruses (rAAV) Produced in iCELLis Nano 4 m2 Adherent Bioreactor

In the clarification of recombinant adeno-associated virus cell culture (rAAV), unwanted cellular material is separated from the vector to increase its purity and enable further downstream processing. In industrial settings, primary clarification with depth filters is used to remove larger particles, such as cells and cellular debris originating from cell lysis and benzonase treatment. To reduce the challenge on the downstream process a clarification step that can eliminate these contaminants with minimal rAAV loss is highly desirable for robust GMP manufacture. We are working towards improving the clarification and downstream steps for rAAV5, 9 and other rAAV subtypes. We produced rAAV on the iCELLis Nano 4 m2 adherent bioreactor with 8 L media. At the point of harvest, the cells were lysed and were treated with benzonase. ‘The upstream feed was assessed for turbidity and subsequently processed and concentrated by depth filtration and Tangential Flow Filtration (TFF) and the reduction in turbidity determined

Müller cell activation, proliferation and migration following laser injury.

PurposeMüller cells are well known for their critical role in normal retinal structure and function, but their reaction to retinal injury and subsequent role in retinal remodeling is less well characterized. In this study we used a mouse model of retinal laser photocoagulation to examine injury-induced Müller glial reaction, and determine how this reaction was related to injury-induced retinal regeneration and cellular repopulation.MethodsExperiments were performed on 3-4-week-old C57BL/6 mice. Retinal laser photocoagulation was used to induce small, circumscribed injuries; these were principally confined to the outer nuclear layer, and surrounded by apparently healthy retinal tissue. Western blotting and immunohistochemical analyses were used to determine the level and location of protein expression. Live cell imaging of green fluorescent protein (GFP)-infected Müller cells (AAV-GFAP-GFP) were used to identify the rate and location of retinal Müller cell nuclear migration.ResultsUpon injury, Müller cells directly at the burn site become reactive, as evidenced by increased expression of the intermediate filament proteins glial fibrillary acidic protein (GFAP) and nestin. These reactive cells re-enter the cell cycle as shown by expression of the markers Cyclin D1 and D3, and their nuclei begin to migrate toward the injury site at a rate of approximately 12 microm/hr. However, unlike other reports, evidence for Müller cell transdifferentiation was not identified in this model.ConclusionsRetinal laser photocoagulation is capable of stimulating a significant glial reaction, marked by activation of cell cycle progression and retinal reorganization, but is not capable of stimulating cellular transdifferentiation or neurogenesis

Aluminium Process Fault Detection and Diagnosis

The challenges in developing a fault detection and diagnosis system for industrial applications are not inconsiderable, particularly complex materials processing operations such as aluminium smelting. However, the organizing into groups of the various fault detection and diagnostic systems of the aluminium smelting process can assist in the identification of the key elements of an effective monitoring system. This paper reviews aluminium process fault detection and diagnosis systems and proposes a taxonomy that includes four key elements: knowledge, techniques, usage frequency, and results presentation. Each element is explained together with examples of existing systems. A fault detection and diagnosis system developed based on the proposed taxonomy is demonstrated using aluminium smelting data. A potential new strategy for improving fault diagnosis is discussed based on the ability of the new technology, augmented reality, to augment operators’ view of an industrial plant, so that it permits a situation-oriented action in real working environments

Mediastinal Pancreatic Pseudocyst With Hemorrhage and Left Gastric Artery Pseudoaneurysm, Managed With Left Gastric Artery Embolization and Placement of Percutaneous Trans-Hepatic Pseudocyst Drainage

Mediastinal pancreatic pseudocyst (MPP) is a rare, but known, complication of both acute and chronic pancreatitis. Most pseudocysts are associated with alcoholic pancreatitis. Recent advances in endoscopic techniques have shown promising results, with reduced chances of infection and recurrence than with percutaneous drainage, but limited availability restricts widespread use. Left gastric artery pseudoaneurysm with mediastinal pseudocyst has not been described in the literature to date. We report a successful resolution of hemorrhagic MPP with embolization of pseudoaneurysm and percutaneous trans-hepatic pseudocyst drainage

High Thrust-to-Power Annular Engine Technology

Gridded ion engines have the highest efficiency and total impulse of any mature electric propulsion technology, and have been successfully implemented for primary propulsion in both geocentric and heliocentric environments with excellent ground/in-space correlation of performance. However, they have not been optimized to maximize thrust-to-power, an important parameter for Earth orbit transfer applications. This publication discusses technology development work intended to maximize this parameter. These activities include investigating the capabilities of a non-conventional design approach, the annular engine, which has the potential of exceeding the thrust-to-power of other EP technologies. This publication discusses the status of this work, including the fabrication and initial tests of a large-area annular engine. This work is being conducted in collaboration among NASA Glenn Research Center, The Aerospace Corporation, and the University of Michigan